Stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from Centella asiatica. If the treatment showed a significant effect on the observed variables then continued with the DMRT test. Content from this work may be used under the terms of the Creative Commons Attribution 3. The effects of CA upon pain antinociception and inflammation in rodent models were reported[ 49 ]. In vitro and In vivo anthelmintic activity of Terminalia arjuna Int. Another current study assessed the antioxidant property in elderly subjects and confirmed the beneficial effects of CAE at doses of and mg per day in elderly patients for 90 days, where, the CAE improved the strength especially in the lower extremities of the elderly[ 84 ].

Pharmacological review on natural antidiarrhoel agents Der Pharma Chemica ; 2 2: Apart from showing a stimulation of the collagen synthesis in different cell types, the asiaticoside were shown to increase the tensile strength of the newly formed skin, furthering the healing of the wounds. Gotu Kola Centella asiatica extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptide. Centella asiatica CA , a clonal, perennial herbaceous creeper belonging to the family Umbellifere Apiceae is found throughout India growing in moist places up to an altitude of m. Sign up for new issue notifications.

Gamma-aminobutyric acid GABA receptor stimulation.

centella asiatica thesis

Both in vivo clinical studies and human monolayer cell culture experiments have concluded centelpa asiatic acid influences collagen synthesis. The standardized CA extracts and asiaticoside were well tolerated in experimental animals especially by oral route.

The therapeutic potential of this plant in terms of its efficacy and versatility is such that further detailed research appears crucial. Centelloside and its derivatives are found to be effective centeola the treatment of venous hypertension. Review on plants with CNS-effects used in traditional South African medicine against mental diseases.


If the treatment showed a significant effect on the observed variables then continued with the DMRT test. Please review our privacy policy.


The study also proved the role of CAE as a natural resource for vigor and strength increase, in healthy elderly persons. Healing was more prominent with the gel product. Centella asiatica zsiatica, description, herb-drug interactions, pharmacology of Centella asiaticapreclinical and clinical studies, side effects, therapeutic uses. Also, a histopathological examination indicated that madecassoside alleviated infiltration of inflammatory cells and synovial hyperplasia as well as provided protection against joint destruction.

centella asiatica thesis

The antiulcer activity was compared to famotidine H 2 -antagonist and sodium valproate antiepleptic or antiseizure. The extracts were subjected to qualitative phytochemical analysis using standard procedures. Modification of the kinetics of healing after iterative exeresis in the rat. CATF proved to be effective on microcirculation and capillary permeability.

Very recently, a study was conducted in sixty elderly subjects in age group 65 and above, using diagnostic tools like Mini Mental State Examination scoring MMSE scoringwherein activities of daily living and Yesavage geriatric depression scale were evaluated[ 75 ]. The levels of basal serum uronic acid and enzymes involved in mucopolysaccharide metabolism beta-glucuronidase, beta-N-acetylglucosaminidase, and arylsulfatase were elevated in patients with varicose veins, indicating an increased muco-polysaccharide turnover.

Antinociceptive and antiinflammatory properties: Indian J Med Res. These results indicated that CA produced different actions on the various phases of wound repair by exhibiting significant wound healing activity in normal as well as delayed healing models[ 23 ].

Protection against radiation-induced conditioned taste aversion by Centella asiatica. A double-blind, placebo-controlled study was conducted to check the effects of an oral standardized CA product in two doses 30 mg bid and 60 mg bid in 87 patients with chronic venous hypertensive microangiopathy[ 67 ].


Centella asiatica, pegaga, learning and memory enhancement, neuroprotective agent.

centella asiatica thesis

Comparative Capillaroscopic study of certain bioflavonoids and total triterpenic fractions of Centella asiatica in venous insufficiency. University Park Press Crossref.

Effects of Centella asiatica on ethanol induced gastric mucosal lesions in rats. Conference SeriesVolumeBiology. Effect of the triterpenoid fraction of Centella asiatica on macromolecules of the connective matrix in human skin fibroblast cultures.

Phytochemical Analysis Of Centella Asiatica L. Leaf Extracts.

Pharmacokinetics of the total triterpenic fraction of Centella asiatica after single and multiple administrations to healthy volunteers. In cases of vascular injury, thrombosis, acute myocardial infarction, and other peripheral vascular diseases, a higher number of circulating endothelial centellw was detected.

Another study demonstrated the protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity when tested on B cell cultures and hippocampal slices. There have been no reports documenting negative interactions between CA and medications to date. The result obtained showed that both type of Centella asiatica showed increased in thickness of dentate gyrus as compared to control group.

A move towards nature. Anti-herpes Simplex Virus activities of crude water extracts of Thai medicinal plants. The extract of CA was tested on 94 patients suffering from venous insufficiency of the lower limbs[ 63 ].