THESIS ON MACROCYTIC ANEMIA

Macrocytosis, mild anemia and delay in diagnosis of pernicious anemia. Although our study had very small number of cases with drug exposure, clinical history of drug intake is essential in evaluating for megaloblastic anemia. The high prevalence of tropical sprue as established in this study has not been revealed in any other study before. Considering megaloblastic anaemia as one of the differentials in pancytopenia is important. Support Center Support Center. Suspicion at high level, properly eliciting the history and thorough examination of the patient will lead us in diagnosing macrocytic anemia.

Interpretation of electronically determined macrocytosis. Suspicion at high level, properly eliciting the history and thorough examination of the patient will lead us in diagnosing macrocytic anemia. Status of laboratory testing in the diagnosis of megaloblastic anemia. To search for and identification of distinct clinical features may help to diagnose megaloblastic anemia and also may help in the early identification of low levels of B12 or folic acid. ABC of clinical hematology: Macrocytic anemia is generally classified as megaloblastic or non-megaloblastic anemia.

This demonstrates that megaloblastosis still remains the most significant reason for macrocytic anemia in our population which causes substantial morbidity. The severity of anemia did not have any correlation with the levels of serum B12 or the degree of macrocytosis.

Please review our privacy policy. Macrocytosis of the erythrocytes: ABC of clinical hematology: Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis.

Clinico-aetiologic profile of macrocytic anemias with special reference to megaloblastic anemia

This emphasises the significance of evaluating tropical sprue in macrocytc suitable settings to the clinician. Disorders that affect the synthesis of DNA in the precursors of erythrocytes leads to megaloblastic anemia and other disorders through various processes causes non-megaloblastic anemia.

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The high prevalence of tropical sprue as established in this study has not been revealed in any other study before. Author information Article notes Copyright and License information Disclaimer. Post splenectomy and pregnant patients. Macrocytic anemia, Non-megaloblastic macrocytic anemia, Bone marrow disorders, Megaloblastic anemia, Myelodysplastic syndrome.

Macrocytic anemia was diagnosed in patients with 1. Macro-ovalocytes and hyper-segmented neutrophils occurring in peripheral blood smear would significantly favour towards diagnosing megaloblastic anemia.

Clinico-aetiologic profile of macrocytic anemias with special reference to megaloblastic anemia

The clinical significance of macrocytosis. Received Jun 3; Accepted Sep Vitamin B12 deficiency may perhaps produce only low grade macrocytic anemia which when persistant for a prolonged duration there is a rapid detoriation, which has been demonstrated in various case studies. Indian J Hematol Blood Transfus. Bleeding was not a presenting complaint in patients with thrombocytopenia due to B12 deficiency.

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thesis on macrocytic anemia

A practical approach to the differential mactocytic and evaluation of the adult patient with macrocytic anemia. Vitamin B 12 deficiency and early rise in MCV.

We observed in our study that being a non vegetarian does not protect against Vitamin B12 deficiency. Three patients mean age 55 years with a megaloblastic marrow did not respond to vitamin replacement and were found to have myelodysplastic syndrome.

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Etiological Profile of Macrocytic Anemia in Patients Admitted in PSG Hospitals

Result The most common cause of macrocytic anemia was megaloblastic anemia The most common cause of macrocytic anemia was megaloblastic anemia Macrocytosis would be seen even in the absence of anemia. Patients above the age of 15 years with macrocytic anemia.

thesis on macrocytic anemia

To search for and identification of distinct clinical features may help to diagnose megaloblastic anemia and also may help in the early identification of low levels of B12 or folic acid.

Published online Jan Sorting out the causes. Often we see macrocytosis preceding anemia4,5,6, which is usually not investigated, particularly when anemia is very mild. The prevalence of tropical sprue is also quite great.

thesis on macrocytic anemia

Abstract Purpose of study Anemiq study was conducted to study the clinical and laboratory parameters in patients with macrocytic anemia and to determine the etiology of macrocytic anemia with special reference to megaloblastic anemia.

Although our study had very small number of cases with drug exposure, clinical history of drug intake is essential in evaluating for megaloblastic anemia. Am J Med Sc.

National Center for Biotechnology InformationU. Badhe2 Zachariah Bobby3 and Ashish K.