THESIS ON SCRUB TYPHUS

In , Kim et al. Scrub typhus in patients reporting with acute febrile illness at a tertiary health care institution in Goa. Genome-based construction of the metabolic pathways of Orientia tsutsugamushi and comparative analysis within the Rickettsiales order. Roopa , 1 K. It also requires considerable training for both performing the test and interpretation of the result. Evaluation of tests for serological diagnosis of scrub typhus. Scrub typhus, a zoonotic disease is one of the most covert emerging and re-emerging Rickettsial infections.

National Center for Biotechnology Information , U. Investigation of an outbreak of scrub typhus in the himalayan region of India. Scrub typhus is widespread, extending from Japan to Australia and from India to Pacific [ 2 ]. Find articles by Belgode Narasimha Harish. Scrub typhus in Darjeeling, India:

The IgM ELISA with good sensitivity and specificity, ease to perform, swift results and also suitable for testing large number of specimens may be considered as good replacement for Weil-Felix test and IFA test in diagnosis of scrub typhus.

Materials and Methods It is a prospective study which was carried out between January to June 3 years 6 monthsin a tertiary care hospital in Puducherry, South India. The name scrub typhus is derived from the prevalence of the mites in areas of heavy scrub vegetation. The diagnosis thessis scrub typhus is generally made by the history and clinical thezis. In a study by Sharma et al.

The most common diagnostic test thrsis India is the Weil-Felix test. Is scrub typhus a cause of febrile illness among paediatric population of delhi?

Open in a separate window. This is hospital based study which has its own limitations, therefore future research can be carried out with community-based study to get more data on seroprevalance of scrub typhus in Pondicherry. Yhesis tests like nested PCR for diagnosis acts as a viable, early and accurate diagnostic tool as compared with that of serological tests.

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Serodiagnosis of Scrub Typhus at a Tertiary Care Hospital from Southern India

Typhus fever in Pondicherry. The patients who had a history of fever with or without eschar and rash and also had more than 2 symptoms such as head ache, myalgia, malaise, nausea, abdominal discomfort were included.

Outbreak of scrub typhus in the North East Himalayan region-Sikkim: There is an upsurge in the incidence of the disease worldwide with ever-changing habitat. Roopa1 K. The test was standardised with serum samples from healthy blood donors.

thesis on scrub typhus

The vast variability and common clinical manifestations of the disease which is similar to other febrile illnesses makes the clinical diagnosis challenging. Jpn J Infect Dis. The cut-off value was obtained by calculating the typhu of optical density OD plus three times of standard deviation SD from serum samples of healthy individuals. A study carried out by Kamarasu et al. The clinical symptoms are fever, headache, myalgia, malaise, rash and lymphadenopathy which are commonly seen in other acute febrile illness like ryphus, enteric fever, leptospirosis, dengue etc.

Comparative evaluation of selected diagnostic assays for the detection of IgG and IgM antibody to Orientia tsutsugamushi in Thailand.

Scrub typhus being the re-emerging zoonosis is increasingly recognised in India. Abstract Introduction Scrub typhus, a zoonotic disease is one of the most covert emerging and re-emerging Rickettsial infections.

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Serodiagnosis of Scrub Typhus at a Tertiary Care Hospital from Southern India

Find articles by Suryanarayana Bettadpura Shamanna. The IFA slide presents antigens from only 3 serotypes namely Karp, Kato and Gilliam, thus unable to detect other antigenically variable strains of Orientia tsutsugamushi affecting the sensitivity of the test [ 14 ]. Scrub typhus in patients reporting with acute febrile illness at a tertiary health care institution in Goa.

Please review our privacy policy. However, it lacks specificity and sensitivity [ 15 ].

thesis on scrub typhus

The patients age varied from 10 months to 80 years were taken for the study. Discussion Scrub typhus being the re-emerging zoonosis is increasingly recognised in India. This article has been cited by other articles in PMC. Author information Article notes Copyright and License information Disclaimer. In developing countries, among the various laboratory tests to diagnose scrub typhus, Weil-Felix test is commonly performed despite its low sensitivity. Indian J Med Res.

The current gold standard is imperfect as it is expensive requiring a fluorescence microscope. Therefore the disease has been urbanised and the prevalence of the disease has broadened further [ 1 ].